Functional Neuroanatomy of the Normal and Pathological Basal Ganglia.

The term "basal ganglia" refers to a group of interconnected subcortical nuclei engaged in motor planning and movement initiation, executive functions, behaviors, and emotions. Dopamine released from the substantia nigra is the underlying driving force keeping the basal ganglia network under proper equilibrium and, indeed, reduction of dopamine levels triggers basal ganglia dysfunction, setting the groundwork for several movement disorders. The canonical basal ganglia model has been instrumental for most of our current understanding of the normal and pathological functioning of this subcortical network.

UTSA-16(Zn) for SO detection: elucidating the fluorescence mechanism.

In this study, the potential of the metal-organic framework UTSA-16(Zn) as a fluorescence detector for SO is explored. The material was synthesized and characterized by powder X-ray diffraction (PXRD), infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA), and its fluorescence behavior was analyzed before and after SO exposure. A significant decrease in fluorescence intensity was observed and a LOD of 1.

Temporal dynamics of neurovascular unit changes following blood-brain barrier opening in the putamen of non-human primates.

Low-intensity focused ultrasound (LIFU) combined with intravenously circulating microbubbles has recently emerged as a novel approach for increasing delivery through the blood-brain barrier (BBB). This technique safely and transiently enables therapeutic agents to overcome the BBB, which typically poses a significant obstacle for treatment of brain disorders. However, the full impact of LIFU on the entire neurovascular unit (NVU), as well as the mechanisms and factors involved in restoring BBB integrity still require further elucidation.

Record-Breaking HS Capture and ppm-Level Sensing with a Chemically Stable Porous Organic Cage.

The first experimental investigation of a porous organic cage (POC) for the challenging task of HS capture is reported. The N-containing cage molecular material, a tertiary amine POC (6FT-RCC3), demonstrates the highest HS (hydrogen sulfide) capture (record capacity) for a porous material at room temperature and atmospheric pressure (20.6 mmol HS g; 25 HS molecules per cage) combined with excellent reversibility for at least five adsorption-desorption cycles.