Publications by authors named "J L Nano"
Background: Sex differences exist in type 2 diabetes (T2D), and androgens have been implicated in the etiology of T2D in a sex-specific manner. We therefore aimed to investigate whether androgens play a role in explaining sex differences in glucose homeostasis and incidence of T2D.
Methods: We used observational data from the German population-based KORA F4 study (n = 1975, mean age: 54 years, 41% women) and its follow-up examination KORA FF4 (median follow-up 6.
Article Synopsis
- Randomized studies suggest that (ultra-)hypofractionation is just as effective as a traditional 5-week radiation schedule for treating postoperative breast cancer, but there's limited data on its long-term impact on secondary cancers.
- A study involving 20 breast cancer patients examined different radiation schedules and found that (ultra-)hypofractionation significantly reduced the risk of secondary malignancies like lung cancer, contralateral breast cancer, and soft tissue sarcoma.
- The results indicated that using (ultra-)hypofractionation could lower the risk of developing secondary malignancies more than conventional scheduling, with varying effects based on the radiation technique (3D-CRT vs. VMAT).
Article Synopsis
- The study investigates the lymphatic drainage to contralateral internal mammary nodes (cIMN) in breast cancer patients and highlights its neglect in current adjuvant radiotherapy practices.* -
- It analyzes the incidental radiation dose to cIMN in 120 advanced treatment plans, noting that higher doses are observed when including internal mammary node irradiation (IMNI) and during free breathing compared to deep inspiration breath hold (DIBH).* -
- The findings indicate that cIMN receives low radiation doses in existing randomized trials and treatment methods, prompting the need for further research on the effects of targeting cIMN in high-risk breast cancer patients.*
Article Synopsis
- Understanding how kidney function ages is crucial for identifying those at risk for chronic kidney disease.
- This study analyzed data from four German cohorts over 25 years, focusing on estimated glomerular filtration rates (eGFR) from blood tests to provide age-specific reference values.
- Findings indicate that eGFR declines linearly with age, and the study offers tools for clinicians to evaluate eGFR based on patients' age and health profiles.
Research has indicated that sex hormone-binding globulin (SHBG) is associated with glucose homeostasis and may play a role in the etiology of type 2 diabetes (T2D). While it is unclear whether SHBG may mediate sex differences in glucose control and subsequently, incidence of T2D. We used observational data from the German population-based KORA F4 study (n = 1937, mean age: 54 years, 41% women) and its follow-up examination KORA FF4 (median follow-up 6.
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