Publications by authors named "J L Mutschler"

Artificial intelligence (AI) offers a wealth of opportunities for medicine, if we also bear in mind the risks associated with this technology. In recent years the potential future integration of AI with medicine has been the subject of much debate, although practical clinical experience of relevant cases is still largely absent. This case study examines a particular patient's experience with different forms of care.

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Introduction: We investigated the antidepressant effects of a novel oral prolonged-release formulation of racemic ketamine (KET01) in patients suffering from treatment-resistant depression (TRD) as add-on therapy.

Material And Methods: Patients were randomized to an additional 160 mg/day or 240 mg/day KET01 or placebo for 14 days. The primary endpoint was change in Montgomery-Åsberg Depression Rating Scale (MADRS) scores from baseline to day 15.

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Article Synopsis
  • Pregabalin, originally approved for conditions like neuropathic pain and anxiety, has seen a significant rise in abuse, especially noted in Swiss prisons and forensic hospitals.
  • A study surveying 131 physicians revealed that 82.5% observed increasing pregabalin use, with 89.1% of patients requesting it without proper medical justification, often in combination with other drugs.
  • Many physicians reported patients taking dangerously high doses (up to 4,200 mg/day) and experiencing withdrawal symptoms, predominantly affecting foreign patients from Northwest Africa, leading to a consensus to reduce or discontinue prescriptions in problematic cases.
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Background: Switzerland ranks among the top three healthcare systems in the world with regards to healthcare access, suggesting a high degree of health equity. However, Switzerland has few preventive strategies against smoking abuse. The aim of this study is to clarify whether educational level and citizenship status have an influence on the prevalence of smoking in Switzerland and whether there is health inequity related to a lack of preventive strategies.

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