Publications by authors named "J L Munson"
The lymph node (LN) performs essential roles in immunosurveillance throughout the body. Developing in vitro models of this key tissue is of great importance to enhancing physiological relevance in immunoengineering. The LN consists of stromal populations and immune cells, which are highly organized and bathed in constant interstitial flow.
View Article and Find Full Text PDFGlioblastoma recurrence is a major hindrance to treatment success and is driven by the invasion of glioma stem cells (GSCs) into healthy tissue that are inaccessible to surgical resection and are resistant to existing chemotherapies. Tissue-level fluid movement, or interstitial fluid flow (IFF), regulates GSC invasion in a manner dependent on the tumor microenvironment (TME), highlighting the need for model systems that incorporate both IFF and the TME. We present an accessible method for replicating the invasive TME in glioblastoma: a hyaluronan-collagen I hydrogel composed of human GSCs, astrocytes, and microglia seeded in a tissue culture insert.
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- Moral injury is being studied as a significant factor affecting the mental health and job satisfaction of healthcare workers (HCWs) due to stressful experiences they encounter.
- A longitudinal study with 473 HCWs showed that witnessing or participating in potentially morally injurious events (PMIEs) increased burnout and turnover intentions, particularly among those who witnessed these events.
- The findings suggest that organizations should address moral injury in HCWs by implementing strategies that consider the types of morally injurious experiences they face in their work.
Article Synopsis
- Scientists created a new way to measure fluid flow in brain tumors using special MRI and a computer tool called Lymph4D.
- The method includes steps like preparing tumor cells, injecting them, taking MRI images, and checking results with a dye.
- This new approach helps researchers understand how fluid moves in tumors, which can help improve treatments for many diseases.
Lymph nodes (LNs) are common sites of metastatic invasion in breast cancer, often preceding spread to distant organs and serving as key indicators of clinical disease progression. However, the mechanisms of cancer cell invasion into LNs are not well understood. Existing in vivo models struggle to isolate the specific impacts of the tumor-draining lymph node (TDLN) milieu on cancer cell invasion due to the co-evolving relationship between TDLNs and the upstream tumor.
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