Publications by authors named "J L Mock"
Front-back asymmetries in endogenous auditory spatial attention.
Atten Percept Psychophys
December 2024
Research on endogenous auditory spatial attention typically uses headphones or sounds in the frontal hemispace, which undersamples panoramic spatial hearing. Crossmodal attention studies also show that visual information impacts spatial hearing and attention. Given the overlap between vision and audition in frontal space, we tested the hypothesis that the distribution of endogenous auditory spatial attention would differ when attending to the front versus back hemispace.
View Article and Find Full Text PDFGlutathione (GSH) is a crucial redox scavenger, essential for maintaining cellular redox balance. This study explores the long-term effects of chronic GSH deficiency on lifespan, motor function, cognitive performance, redox status and inflammation. GCLM mice, with a 70-90% reduction in GSH levels, were compared to GCLM controls across their lifespan (5, 10 and 20 months).
View Article and Find Full Text PDFAcute myeloid leukemia (AML) derives from hematopoietic stem and progenitor cells (HSPCs). To date, no AML-exclusive, non-HSPC-expressed cell-surface target molecules for AML selective immunotherapy have been identified. Therefore, to still apply surface-directed immunotherapy in this disease setting, time-limited combined immune-targeting of AML cells and healthy HSPCs, followed by hematopoietic stem cell transplantation (HSCT), might be a viable therapeutic approach.
View Article and Find Full Text PDFArticle Synopsis
- Fibroblast activation protein (FAP) is commonly found in the stroma of human tumors, making it a target for cancer detection using radiolabeled ligands, such as the newly discovered OncoFAP, which shows rapid tumor accumulation and low healthy tissue uptake.
- A trimerized version called OncoFAP-23 has improved binding affinity and was tested in tumor-bearing mice, demonstrating a favorable biodistribution profile with significant tumor retention and minimal healthy tissue accumulation.
- Combining OncoFAP-23 with the interleukin 2 treatment shows increased anti-tumor effects and a strong immune response, while also displaying a good safety profile with no observed toxicity.
Purpose: Listening effort is a broad construct, and there is no consensus on how to subdivide listening effort into dimensions. This project focuses on the subjective experience of effortful listening and tests if cognitive workload, mental fatigue, and mood are interrelated dimensions.
Method: Two online studies tested young adults ( = 74 and = 195) and measured subjective workload, fatigue (subscales of fatigue and energy), and mood (subscales of positive and negative mood) before and after a challenging listening task.