Publications by authors named "J L Meynard"
Article Synopsis
- Human metapneumovirus (hMPV) is a major cause of respiratory infections, and this study focused on adult patients with hMPV-related lower respiratory tract infections to evaluate their clinical features and outcomes.
- A total of 208 patients were studied, with a median age of 74 years; most patients had coexisting health issues, and common symptoms included difficulty breathing and cough, while pneumonia was the most frequent diagnosis.
- The study found that 18% of patients had a complicated course requiring intensive care, with a notable increased risk in those with bacterial coinfections, suggesting the need for careful monitoring and potential early intervention in this population.
A case of a male with human immunodeficiency virus with plasma genotyping detecting no resistance and a CRF02_AG subtype had a controlled HIV RNA on antiretroviral therapy since 2010. We introduced intramuscular therapy with cabotegravir and rilpivirine. One month later, his HIV RNA was 1500 copies/mL; genotyping found a subtype B with many mutations.
View Article and Find Full Text PDFThe emergence of SARS-CoV-2 Omicron variant has led to a complete reconfiguration of the therapeutic landscape, with all monoclonal antibodies having lost any neutralization activity. We report here a case series of 75 immunocompromised patients infected by the Omicron variant who benefited from COVID-19 convalescent plasma (CCP). At Day 28, the overall survival was 76% (95% CI 67-86) with no significant difference in the clinical outcome between patients with hematological malignancies, solid organ transplantation or autoimmune diseases.
View Article and Find Full Text PDFAPOBEC-Induced Mutations at Initiation of Cabotegravir + Rilpivirine for Two Patients Infected by HIV-1 Subtype CRF02: The Interest of Systematic Genotyping.
J Acquir Immune Defic Syndr
March 2023
Background: Many studies have reported weight gain in ART-naive people living with HIV (PWH) initiating an integrase strand-transfer inhibitor-based regimen. We studied the impact of early or advanced presentation and that of individual drugs in PWH initiating combined ART (cART) between 2012 and 2018.
Methods: From the French Hospital Database HIV cohort, we assessed factors associated with a weight gain ≥10%, weight change after cART initiation or BMI increase ≥5 kg/m2 up to 30 months.