Publications by authors named "J L Mclaughlin"
Article Synopsis
- The use of well-structured ontologies and ontology-aware tools enhances data and analyses to be FAIR (Findable, Accessible, Interoperable, Reusable), supporting effective lexical searches and biologically meaningful annotation grouping.
- Researchers face challenges in adopting ontologies, primarily due to their complexity and the tendency to create simplified hierarchies that may misuse relationship types, leading to ineffective organization.
- A suite of validation tools is introduced to help users align their hierarchies with established ontology structures, providing graphical reports and tailored views for various atlases like the HuBMAP Human Reference Atlas and the Human Developmental Cell Atlas.
Introduction: The field of genomics is rapidly evolving and has made significant impact on the diagnosis and understanding of rare and genetic diseases, in guiding precision medicine in cancer treatment, and in providing personalized risk assessment for disease development and treatment responses. However, according to the literature, there is widespread socio economic and racial inequities in the diagnosis, treatment, and in the use of genomic medicine services. This policy review sets out to explore the concept of equity in access to genomic care, the level of inclusion of equity and how it is addressed and what mechanisms are in place to achieve equity in genomic care in the international health policy.
View Article and Find Full Text PDFLateral flow assays are widely used in point-of-care diagnostics but face challenges in sensitivity and accuracy when detecting low analyte concentrations, such as thyroid-stimulating hormone biomarkers. This study aims to enhance assay performance by leveraging textural features and hybrid artificial intelligence models. A modified Gray-Level Co-occurrence Matrix, termed the Averaged Horizontal Multiple Offsets Gray-Level Co-occurrence Matrix, was utilised to compute the textural features of the biosensor assay images.
View Article and Find Full Text PDFEffectiveness of the BNT162b2 XBB.1.5-adapted vaccine against COVID-19 hospitalization related to the JN.1 variant in Europe: a test-negative case-control study using the id.DRIVE platform.
EClinicalMedicine
January 2025
Background: Prior studies have reported lower effectiveness of XBB.1.5-adapted vaccines against hospitalization related to the Omicron JN.
View Article and Find Full Text PDFIntroduction: There is conflicting data in the literature regarding the clinical utility of wearable devices. This study examined the association between patient reported outcome measures (PROMs) and step and stair flight counts obtained from wearable devices in postoperative total hip arthroplasty (THA) patients.
Methods: Data was collected from a multicenter prospective longitudinal cohort study from October 2018 to February 2022.