Publications by authors named "J L Mazzei"
Assessment of in vitro and in silico Antiproliferative Effects of p-Cymene and Its Naturally Occurring 7-Oxygenated Derivatives on Human Cancer Cell Lines.
Asian Pac J Cancer Prev
October 2024
Article Synopsis
- - The study aimed to assess the anticancer effects of compounds like p-cymene and cumin aldehyde on human cancer cell lines through both laboratory (in vitro) tests and computer modeling (in silico) methods.
- - Cumin aldehyde showed a significant reduction in the growth of Calu-3 cells, but no other compounds demonstrated notable antiproliferative effects, with p-cymene being the most toxic overall.
- - The findings suggest that, apart from cumin aldehyde, most tested compounds lack anticancer effectiveness, emphasizing the need for further research on promising candidates with better activity predictions.
Two unusual phorbol esters, namely 20-deoxyphorbol-3,4,12-triacetate-13-phenylacetate () and phorbol-3,4,12,13-tetraacetate-20-phenylacetate () plus ingol-3,8,12-triacetate-7-phenylacetate () were isolated from the latex of and identified by HRESIMS and 2D NMR. Compound is herein described for the first time. Assignment of the phenylacetyl group at C-7 in compound was suggested by the HMBC and NOESY spectra obtained in pyridine-.
View Article and Find Full Text PDFIn Brazil, latex from Euphorbia umbellata (African milk tree) has been increasingly used in folk medicine to treat several types of cancer, including melanoma. The effect of lyophilized latex (LL), its hydroethanolic extract (E80), triterpene (F-TRI)- and diterpene (F-DIT)-enriched fractions, along with six isolated phorbol esters from LL and phorbol 12-myristate 13-acetate (PMA) on J774A.1, THP-1, SK-MEL-28, and B16-F10 cell line viability were evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method.
View Article and Find Full Text PDF(UT) is a medicinal plant popularly known as cat's claw belonging to the Rubiaceae family that has been reported to display antiviral and anti-inflammatory activities. The chikungunya virus (CHIKV) outbreaks constitute a Brazilian public health concern. CHIKV infection develops an abrupt onset of fever, usually accompanied by a skin rash, besides incapacitating polyarthralgia.
View Article and Find Full Text PDFSoursop () is a tropical tree whose decoction derived from bark, root, seed, or leaf has been used for medicinal uses. In addition, the fruit itself is considered a food, and the juice is utilized to treat heart and liver diseases. The aim of this study was to determine the phenolic content.
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