Publications by authors named "J L Markley"
Public health authorities are broadly promoting a strategy known as pre-exposure prophylaxis (PrEP) for the prevention of human immunodeficiency virus (HIV) transmission in the context of high-risk sexual activity and injection drug use. However, there are several limitations to this strategy that are underrecognized. This article reviews the primary literature supporting the use of PrEP and explores the unintended consequences associated with its use.
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- The study analyzes the changing patterns and effectiveness of secondary spontaneous bacterial peritonitis (SecSBPPr) prophylaxis in veterans who survived their first SBP episode between 2009-2019.
- It found that around 54% of the veterans were prescribed SecSBPPr, but this treatment increased the risk of SBP recurrence by 63-68%, along with a notable rise in fluoroquinolone resistance.
- The authors suggest that due to the increased risks, there should be a reevaluation of the use of secondary prophylaxis in patients with liver cirrhosis.
COVID-19 and myocardial injury: Targeting elevated biomarkers for potential novel therapies.
Clinics (Sao Paulo)
September 2024
Background: The prevalence of COVID-19 as the primary diagnosis among hospitalized patients with myocardial injury has increased during the pandemic and targeting elevated oxidant stress and inflammatory biomarkers may offer a potential role for novel therapies to improve outcomes.
Methods: At a single VA Medical Center from January 1 through December 31, 2021, troponin assays from patients being evaluated in the Emergency Room for consideration of admission were analyzed and peak levels from each patient were considered abnormal if exceeding the Upper Reference Limit (URL). Among admitted patients with an elevated troponin level, ICD-10 diagnoses were categorized, biomarker elevations were recorded, and independent predictors of death in patients with COVID-19 were determined at a median of 6-months following admission.
A one-pot, sequential phosphate tether-mediated method for the synthesis of simplified 2-desmethyl sanctolide A analogs is reported. Western side-chain diversification was achieved using a pot-efficient, sequential cross metathesis (CM)/ring-closing metathesis (RCM)/H/dephosphorylation procedure. Further diversification was achieved by MeAl-mediated amide formation, Yamaguchi esterification, and RCM macrocyclization to access five C11/C12 -configured, 2-des-methyl sanctolide A analogs with improved stability.
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