Publications by authors named "J L Liberona"
Article Synopsis
- The study investigates how reducing dietary chloride (Cl-) while maintaining normal sodium (Na+) levels affects blood pressure and related health factors in mice subjected to high blood pressure conditions induced by angiotensin II (AngII).
- Mice on a standard Cl- diet showed increased systolic blood pressure (SBP) and cardiac hypertrophy after AngII infusion, while those on a low-Cl- diet did not experience these negative effects.
- The findings suggest that a low-Cl- diet helps protect against the harmful impacts of AngII by improving kidney function and maintaining the body's ability to expel sodium (natriuresis).
Article Synopsis
- Oxidative stress from renal ischemia-reperfusion injury (IRI) causes damage to kidney cells, leading to inflammation and loss of kidney function, particularly during transplants.
- The study evaluates aminoguanidine (AG) as an antioxidant treatment, assessing its effects on various molecular pathways and injury markers in the kidney following IRI.
- Results show AG successfully prevents lipid peroxidation, boosts protective antioxidant levels, and reduces inflammation and kidney injury, suggesting it could be a valuable therapy for minimizing damage during renal IRI.
Background/aims: Renal ischemia and reperfusion injury (IRI) involves oxidative stress, disruption of microvasculature due to endothelial cell damage, loss of epithelial cell polarity secondary to cytoskeletal alterations, inflammation, and the subsequent transition into a mesenchymal phenotype. Ischemic preconditioning (IPC) has been proposed as a therapeutic strategy to avoid/ameliorate the IRI. Since previous results showed that IPC could have differential effects in kidney cortex vs.
View Article and Find Full Text PDFOn renal ischemia-reperfusion (I/R) injury, recruitment of neutrophils during the inflammatory process promotes local generation of oxygen and nitrogen reactive species, which, in turn, are likely to exacerbate tissue damage. The mechanism by which inducible nitric oxide synthase (iNOS) is involved in I/R has not been elucidated. In this work, the selective iNOS inhibitor l- N-(1-iminoethyl)lysine (l-NIL) and the NOS substrate l-arginine were employed to understand the role of NOS activity on the expression of particular target genes and the oxidative stress elicited after a 30-min of bilateral renal ischemia, followed by 48-h reperfusion in Balb/c mice.
View Article and Find Full Text PDFUnlabelled: Background. Patients with type 2 diabetes mellitus (T2DM) are at risk for developing end-stage liver disease due to nonalcoholic steatohepatitis (NASH), the aggressive form of non-alcoholic fatty liver disease (NAFLD). Data on prevalence of advanced fibrosis among T2DM patients is scarce.
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