Publications by authors named "J L Leatherwood"
Previously, Tuller et al. found that the first 30-50 codons of the genes of yeast and other eukaryotes are slightly enriched for rare codons. They argued that this slowed translation, and was adaptive because it queued ribosomes to prevent collisions.
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- The study investigated the effects of the bisphosphonate clodronate disodium (CLO) on bone health in juvenile sheep over 165 days, analyzing factors like bone turnover, density, and microstructure.
- Forty juvenile sheep were divided into four treatment groups, including a control and three that received CLO at different times, while they were exercised regularly and monitored for physical changes.
- Results showed no significant effects of CLO on the sheep's skeleton, with minor changes in serum bone biomarkers attributed to time and exercise, suggesting the need for further research on low-dose bisphosphonates in active juvenile populations.
Objective: To determine the single-dose pharmacokinetics of clodronate disodium (CLO) in juvenile sheep and the plasma protein binding (PPB) of CLO in juvenile sheep and horses.
Animals: 11 juvenile crossbred sheep (252 ± 6 days) for the pharmacokinetic study. Three juvenile crossbred sheep (281 ± 4 days) and 3 juvenile Quarter Horses (599 ± 25 days) for PPB analysis.
Thirty stock type geldings (15 ± 3 years; 556 ± 63 kg BW) were used in a randomized complete design over 28 days to determine the influence of cannabidiol (CBD) oil supplementation levels on body weight, body condition, and blood chemistry. Horses were randomly assigned to one of three dietary treatments (n = 10 per treatment) formulated with canola oil to provide 1.50 mg CBD/kg BW (TRTA), 0.
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