Publications by authors named "J L Lauermann"
Effects of beta-blockers on quality of life and well-being in patients with myocardial infarction and preserved left ventricular function-a prespecified substudy from REDUCE-AMI.
Eur Heart J Cardiovasc Pharmacother
January 2025
Aims: In the Randomized Evaluation of Decreased Usage of Beta-Blockers after Acute Myocardial Infarction (REDUCE-AMI) study, long-term beta-blocker use in patients after acute myocardial infarction (AMI) with preserved left ventricular ejection fraction demonstrated no effect on death or cardiovascular outcomes. The aim of this prespecified substudy was to investigate effects of beta-blockers on self-reported quality of life and well-being.
Methods And Results: From this parallel-group, open-label, registry-based randomized clinical trial, EQ-5D, and World Health Organization well-being index-5 (WHO-5) questionnaires were obtained at 6-10 weeks and 11-13 months after AMI in 4080 and 806 patients, respectively.
Article Synopsis
- - The study investigated whether fractional flow reserve (FFR)-guided complete revascularization improved outcomes compared to treating only the culprit lesion in patients with STEMI or high-risk NSTEMI and multivessel coronary artery disease.
- - A total of 1542 patients participated, with similar rates of adverse event occurrences (death, myocardial infarction, or unplanned revascularization) between the complete revascularization group (19.0%) and the culprit-lesion-only group (20.4%) over a median follow-up of 4.8 years.
- - The findings suggest that FFR-guided complete revascularization did not significantly reduce the risk of major adverse outcomes compared to only addressing the culprit lesion, indicating
Article Synopsis
- - The IAMI trial studied 2571 patients with acute myocardial infarction to assess the impact of influenza vaccination on cardiovascular events, comparing outcomes between early and late season vaccinations over a 12-month period.
- - Results showed no significant difference in the effectiveness of the vaccine whether given early or late, with similar percentages of primary composite endpoints observed in both groups (6% early, 4.7% late for vaccinated participants).
- - Although early vaccination demonstrated a potentially greater effect on overall mortality, the findings were not statistically significant; thus, the study reinforces recommending influenza vaccination for all cardiovascular patients, regardless of timing.
The adenosine-requiring physiological index fractional flow reserve (FFR) is the gold-standard method for determining the significance of intermediate lesions, while the resting full-cycle ratio (RFR) is a novel nonhyperaemic index without the need for adenosine administration. The aim of this study was to investigate the degree of concordance between RFR and FFR in indicating the need for revascularisation in patients with intermediate coronary lesions. This was a retrospective, registry-based study utilising data from the SWEDEHEART registry.
View Article and Find Full Text PDFThe aim of this study was to use deep learning based on a deep convolutional neural network (DCNN) for automated image classification of healthy optic discs (OD) and visible optic disc drusen (ODD) on fundus autofluorescence (FAF) and color fundus photography (CFP). In this study, a total of 400 FAF and CFP images of patients with ODD and healthy controls were used. A pre-trained multi-layer Deep Convolutional Neural Network (DCNN) was trained and validated independently on FAF and CFP images.
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