Publications by authors named "J L Jinks"
Article Synopsis
- Bladder exstrophy (BEX) is a rare condition where the bladder is exposed due to a developmental issue, leading to abnormal cell growth that can persist even after surgical treatment.
- *In a study, epithelial cells from 11 BEX patients were tested in a lab to see if they could form effective barriers similar to normal bladder cells, with 8 out of 11 showing potential for creating these barriers.
- *The research indicated that squamous-type cells had a reduced ability to form tight barriers and suggested that disruptions in certain gene expressions may explain the differences in cell types observed in BEX, which could help guide treatment decisions.
A key element for the prevention and management of coronavirus disease 2019 is the development of effective therapeutics. Drug combination strategies offer several advantages over monotherapies. They have the potential to achieve greater efficacy, to increase the therapeutic index of drugs and to reduce the emergence of drug resistance.
View Article and Find Full Text PDFBackground: Numerous studies have documented the in vitro differentiation of human pluripotent stem cells (hPSCs) into kidney cells. Fewer studies have followed the fates of such kidney precursor cells (KPCs) inside animals, a more life-like setting. Here, we tested the hypothesis that implanting hPSC-derived KPCs into an in vivo milieu surgically engineered to be highly vascular would enhance their maturation into kidney tissues.
View Article and Find Full Text PDFGABA(A) receptors containing α2/3 subunits are current targets in the battle to develop new pain medications, as they are expressed in the spinal cord where increasing inhibitory drive should result in analgesia. However, this approach is prone to a range of side effects including sedation, cognitive impairment, and abuse as a consequence of the widespread influence of GABA. The ability to make subtype selective low-efficacy benzodiazepine compounds, which potentiate the action of GABA at specific α subunits, has the potential to reduce this side effect profile.
View Article and Find Full Text PDFA 7-year-old, spayed female mixed breed dog was evaluated for labored breathing, lethargy, and a distended abdomen. Pericardial effusion was diagnosed after radiographic and echocardiographic interpretation. Treatment consisted of thoracocentesis and a single pericardiocentesis.
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