Selectivity and anti-tumor immune elevation by vascular-targeted photodynamic therapy of mouse orthotopic bladder cancer model.

Vascular-targeted photodynamic therapy (VTP) with WST11 is a non-surgical tumor ablation approach that is currently being tested in a phase 3 clinical trial for the treatment of upper tract urothelial cancer. WST11-VTP utilizes illumination, leading to hypoxia, and production of free radicals followed by coagulative necrosis. Here, we tested the hypothesis that WST11-VTP can safely ablate muscle-invasive MB-49- luc bladder tumors in an orthotopic mouse model while sparing the surrounding normal tissue.

Carrier Multiplication and Photoexcited Many-Body States in Solution-Processed 2H-MoSe.

Carrier multiplication (CM), where a single high-energy photon generates multiple electron-hole pairs, offers a promising route to enhance the efficiency of solar cells and photodetectors.Transition metal dichalcogenides, such as 2H-MoTe and 2H-WSe, exhibit efficient CM. Given the similar electronic band structure of 2H-MoSe, it is expected to show comparable CM efficiency.

A Pilot Study of CT Simulator Downtime at an African Cancer Conference: Survey Results from AORTIC 2023.

Purpose: CT simulation is required for centers performing 3D conformal radiotherapy and intensity modulated radiation therapy. Therefore, CT simulator downtime is likely to lead to delays in patient care. We sought to characterize CT simulator downtime within the African context.

Flexible thermoelectric generators from spray-printed PEDOT:PSS/BiSbTe composites.

Energy harvesting technologies play a pivotal role in powering the next generation of wearable and portable devices, where thin-film thermoelectric generators (TEGs) offer a compact and flexible solution. In this study, flexible thin films of poly(3,4-ethylenedioxythiophene)polystyrene sulfonate (PEDOT:PSS)/BiSbTe composite on flexible polymeric substrates were initially developed using a spray printing technique. The effect of substrate temperature during printing was assessed on the microstructural and thermoelectric properties, yielding a maximum power factor at a substrate temperature of 110 °C.