Objective: To investigate the influence of four major life events (leaving home, full-time employment, married/cohabiting, parenthood) and socio-demographic variables on risky total leisure noise (TLN) during transition to adulthood with a special focus on visiting discotheques and listening to portable listening devices (PLDs).
Design: Longitudinal analysis of the OHRKAN cohort. Risky TLN covering 22 activities was defined as exceeding 85 dB(A) averaged over a 40-hour week.
Background: Inpatient psychiatric facilities have an increased risk of infection transmission. This study evaluated the impact of roommate and unit mate exposures on coronavirus disease-2019 (COVID-19) transmission to inform isolation practices.
Methods: A single-center retrospective study was conducted among patients hospitalized in an inpatient behavioral health hospital from July 2020 through August 2023.
Unlabelled: Serious games are increasingly being applied within healthcare, but their integration in psychotherapeutic settings is less documented.
Objectives: The present study sought to identify the attitudes of psychotherapists and patients towards the hypothetical use of serious games in psychotherapy in the South African context.
Methods: Online surveys assessed acceptance, experience, and requirements for the utilisation of serious games in therapeutic contexts.
NADPH oxidase (NOX) is a primary mediator of superoxides, which promote oxidative stress, neurodegeneration, and neuroinflammation after diisopropylfluorophosphate (DFP) intoxication. Although orally administered mitoapocynin (MPO, 10 mg/kg), a mitochondrial-targeted NOX inhibitor, reduced oxidative stress and proinflammatory cytokines in the periphery, its efficacy in the brain regions of DFP-exposed rats was limited. In this study, we encapsulated MPO in polyanhydride nanoparticles (NPs) based on 1,6-bis(p-carboxyphenoxy) hexane (CPH) and sebacic anhydride (SA) for enhanced drug delivery to the brain and compared with a high oral dose of MPO (30 mg/kg).
View Article and Find Full Text PDF