Publications by authors named "J L Harkness"
Immune responses to tumors, comprising adaptive T cells and innate NK cells, arise very early in tumorigeneses and prior to detection of palpable tumors or before tissue pathology is evident. Yet, how nascent tumors evoke dendritic cell maturation and the resulting cytokine responses that are necessary for these effector anti-tumor immune responses is unknown. We have previously shown that CD91 expression on dendritic cells is important for immune surveillance, specifically for generating T cell and NK cell responses to nascent tumors.
View Article and Find Full Text PDFObjectives: (i) To identify peer reviewed publications reporting the mental and/or physical health outcomes of Deaf adults who are sign language users and to synthesise evidence; (ii) If data available, to analyse how the health of the adult Deaf population compares to that of the general population; (iii) to evaluate the quality of evidence in the identified publications; (iv) to identify limitations of the current evidence base and suggest directions for future research.
Design: Systematic review.
Data Sources: Medline, Embase, PsychINFO, and Web of Science.
Objective: Although regurgitant mitral valves can be repaired through surgical or transcatheter approaches, contemporary comparative outcomes are limited with the impact of residual and recurrent mitral regurgitation (MR) on clinical outcomes being poorly defined. We hypothesized that moderate (2+) or greater residual or recurrent (RR) MR-regardless of type of repair-predicts worse clinical outcomes.
Methods: Our institutional experience of 660 consecutive patients undergoing mitral valve repair (2015-2021) consisting of 393 surgical mitral valve repair (SMVr) and 267 transcatheter edge-to-edge mitral valve repair (TEER) was studied.
Article Synopsis
- Genetic variants in the ATP7A gene are linked to various X-linked disorders, with Menkes disease being the most severe and other conditions like occipital horn syndrome and X-linked distal spinal muscular atrophy following.
- A comprehensive study identified a rare deep intronic variant in four males from the same family, leading to skeletal issues such as bone bowing and joint dislocations, along with other symptoms like curly hair and motor coordination challenges.
- Research highlighted that this variant causes abnormal splicing of the ATP7A gene, resulting in transcripts that likely lead to dysfunctional proteins, and suggests that the varying symptoms among the affected individuals may be due to differences in splicing effects.