Publications by authors named "J L H Chakrabarty"
Article Synopsis
- - Research on patients with normal pressure hydrocephalus (NPH) indicates that early Alzheimer's disease (AD) pathology can be detected, and this study aims to identify cerebrospinal fluid (CSF) biomarkers related to these initial AD changes.
- - The study analyzed CSF data and found that specific biomarkers such as β-amyloid-42/40 and neurofilament light chain (NfL) are correlated with AD pathology; seven key proteins were identified that also relate to both pathology and gene expression.
- - The findings suggest a link between CSF biomarkers and central nervous system changes in AD, providing valuable insights into how these markers reflect the disease's progression.
Elevated temperature impairs gonadal development by suppressing the expression of the genes for kisspeptin, GnRH1 and GTH subunits in Nile tilapia Oreochromis niloticus.
Comp Biochem Physiol A Mol Integr Physiol
November 2024
Article Synopsis
- * Key reproductive genes, including kiss2, gnrh1, and their receptors, showed decreased expression at higher temperatures (37 °C), leading to reduced gonadotropin levels in the pituitary.
- * Histological analysis revealed normal gamete growth at a control temperature (31 °C), but slowed spermatogenesis and oocyte maturation, along with atretic oocytes, at the higher temperature (37 °C).
Introduction: Normal pressure hydrocephalus (NPH) patients undergoing cortical shunting frequently show early AD pathology on cortical biopsy, which is predictive of progression to clinical AD. The objective of this study was to use samples from this cohort to identify CSF biomarkers for AD-related CNS pathophysiologic changes using tissue and fluids with early pathology, free of post-mortem artifact.
Methods: We analyzed Simoa, proteomic, and metabolomic CSF data from 81 patients with previously documented pathologic and transcriptomic changes.
Here, we investigated the mechanisms by which aging-related reductions of the levels of in skeletal muscle fibers contribute to loss of muscle strength and power, two critical features of sarcopenia. Numb is an adaptor protein best known for its critical roles in development, including asymmetric cell division, cell-type specification, and termination of intracellular signaling. expression is reduced in old humans and mice.
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