Augmenting rehabilitation robotics with spinal cord neuromodulation: A proof of concept.

Rehabilitation robotics aims to promote activity-dependent reorganization of the nervous system. However, people with paralysis cannot generate sufficient activity during robot-assisted rehabilitation and, consequently, do not benefit from these therapies. Here, we developed an implantable spinal cord neuroprosthesis operating in a closed loop to promote robust activity during walking and cycling assisted by robotic devices.

Evolution in the Peri-Implant Oral Microbiome and Their Relationship to Long-Term Marginal Bone Loss: A Randomized Clinical Study.

Objectives: To analyze the clinical, radiographic, and microbiological changes around implants with a multiphosphonate-treated surface, prosthetically loaded with two different protocols after 5 years of functional loading.

Material And Methods: A randomized clinical trial was designed to initiate prosthetic loading over single dental implants after 8 (control) or 4 weeks (test). Several variables were analyzed, including patients' level variables, intrasulcular biofilm, and marginal bone level at several time points, from 1 to 60 months after loading.

Genetic variation in RYR1 is associated with heart failure progression and mortality in a diverse patient population.

Introduction: Heart failure (HF) is a highly prevalent disease affecting roughly 7 million Americans. A transcriptome-wide analysis revealed upregulation in HF patients with severe pulmonary hypertension. Therefore, we aimed to further characterize the role of in HF progression and mortality.

Insights Gained From an Ultrarare Case of Progressive Osseous Heteroplasia With Severe Complications.

Progressive osseous heteroplasia (POH) is an exceptionally rare genetic disorder characterized by progressive heterotopic ossification of cutaneous, subcutaneous, and deep connective tissues. Most cases are associated with paternally inherited inactivating mutations in the guanine nucleotide-binding protein, alpha-stimulating gene. However, the genetic basis remains undefined in a subset of patients, adding further complexity to its pathogenesis.

Can the interleukin TNF-α be used as a biomarker for pulp necrosis?

N/A.