EPR17341 and A7H6R pan-TRK Immunohistochemistry Result in Highly Different Staining Patterns in a Series of Salivary Gland Tumors.

Patients with NTRK-rearranged tumors can be now treated using anti-TRK-targeted therapies making NTRK testing important for treatment choices in patients with advanced cancers. Pan-TRK immunohistochemistry (IHC) could be a valuable premolecular screening strategy in this field. The choice of 1 IHC method or another requires to investigate for intermethod comparison.

Testing for fusions in patients with advanced // wild-type melanomas permits to identify patients who could benefit of anti-MEK targeted therapy.

Beyond targeted therapy for patients with -mutated melanomas and immunotherapy in patients lacking mutations, anti-MEK therapy has been proposed in patients with advanced melanomas harbouring fusions. fusions diagnosis in patients with advanced melanomas is the subject of the present study. Using fluorescent in situ hybridisation (FISH), we searched for fusions in 74 samples of 66 patients with advanced // wild-type melanomas.

[Childhood memories…].

Leprosy is still a largely worldwide spread disease but rarely encountered in metropolitan France. Its identification implies a multidisciplinary clinical, pathological and bacteriological diagnosis which is necessary to an efficient antibiotic treatment against a crippling disease which remains curable. Here we report the case of a 24-year-old man who was showing an original both cutaneous and pulmonary presence of acido-alcooloresistant bacillus which have been identified as Mycobacterium leprae by polymerase chain reaction (PCR).

[Tuberculous pericarditis: still a relevant disease].

Vaccination against tuberculosis is not an obligation anymore in France, except for children at risk, but this disease remains not so rare, including its extrapulmonary forms. The authors report the case of a 27-year-old Madagascan HIV seronegative patient, who developed a pericardial effusion when coming back from a long stay in Madagascar. An anti-inflammatory treatment and then a probabilistic antibiotic treatment were ineffective, and at the same time echocardiographic signs of tamponade appeared.