Biomarkers.

Background: Persistent neurological symptoms including cognitive impairment can follow SARS-CoV-2 infection, a condition termed neurological post-acute sequelae of COVID-19 (Neuro-PASC). Structural brain differences have been observed in individuals with Neuro-PASC, raising concern that COVID-19 may promote age-related neurodegeneration. However, the mechanisms by which COVID-19 impairs cognition and its impact on brain aging, remain poorly characterized.

Rheumatoid Arthritis: A Rare Cause of Pachymeningitis and Optic Neuritis.

Introduction: Rheumatoid pachymeningitis and optic neuritis are rare complications of rheumatoid arthritis (RA) and are a diagnosis of exclusion.

Case Description: A 75-year-old male with a history of seronegative RA presented to the emergency department with left eye pain and blurry vision lasting two days. He had been diagnosed with seronegative RA around nine months previously.

Increased Intracranial Pressure in Myelin-Oligodendrocyte Glycoprotein Antibody-Associated Disease.

Objectives: To assess characteristics of increased intracranial pressure (ICP) in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD).

Methods: This is a multicenter retrospective review of 84 MOGAD cases at the University of Florida, Baylor College of Medicine, the University of California San Diego, and Providence Health and Services, Portland, Oregon, to identify cases with a documented increased opening pressure >25 cm H2O. A literature review was conducted to identify previously reported MOGAD cases with an opening pressure >25 cm H2O.

Imprinting of the paternal marsupial X chromosome by DNA methylation.

Why is it that the X chromosome that comes from the male parent is inactivated in female marsupials, female mice, and even female mealy bugs, or the whole paternal chromosome complement in some weird flies? A new paper by Milton et al. now reveals DNA methylation patterns established in the male germline before meiosis in wallabies that may constitute the elusive paternal imprint.