Impact of a cell salvage device on blood transfusions to dogs undergoing surgery at a referral veterinary hospital.

Objective: To determine the number of homologous blood transfusions received by canine surgical patients after introducing a cell salvage device (CSD), trends in surgeries requiring blood transfusion, and the incidence of transfusion reactions.

Study Design: Retrospective study.

Setting: Single referral hospital.

Ex vivo evaluation of a novel cell salvage device to recover canine erythrocytes.

Objective: To determine the ability of a cell salvage device to recover canine erythrocytes by direct aspiration of diluted packed red blood cells (pRBC) and saline rinse from blood-soaked surgical swabs.

Study Design: Experimental study.

Sample Population: Twelve recently expired units of canine pRBC.

Intraoperative cell salvaging: ex vivo evaluation of two swab-washing methods.

Objective: To compare erythrocyte recovery by a cell salvage device between swab-washing by manual agitation or filtration.

Sample: 12 recently expired units of canine packed RBCs.

Procedure: The packed RBC units underwent quality analysis before donation from a pet blood bank.

Prevalence of pulmonary nodules suggestive of metastasis at presentation in dogs with cutaneous or subcutaneous soft tissue sarcoma.

Objective: To investigate the prevalence of pulmonary nodules suggestive of metastasis at the time of initial presentation in dogs with cutaneous or subcutaneous soft tissue sarcomas (STSs) and no previous related thoracic diagnostic imaging.

Animals: 146 client-owned dogs with a cutaneous or subcutaneous STS.

Procedures: Medical records were retrospectively searched to identify dogs with STSs that underwent initial thoracic diagnostic imaging when presented for referral examination between September 2014 and March 2018.

Hyperpolarisation of cultured human chondrocytes following cyclical pressure-induced strain: evidence of a role for alpha 5 beta 1 integrin as a chondrocyte mechanoreceptor.

Mechanical stimuli influence chondrocyte metabolism, inducing changes in intracellular cyclic adenosine monophosphate and proteoglycan production. We have previously demonstrated that primary monolayer cultures of human chondrocytes have an electrophysiological response after intermittent pressure-induced strain characterised by a membrane hyperpolarisation of approximately 40%. The mechanisms responsible for these changes are not fully understood but potentially involve signalling molecules such as integrins that link extracellular matrix with cytoplasmic components.