Effects of Lactate on Corticospinal Excitability: A Scoping Review.

Aerobic exercise has been shown to impact corticospinal excitability (CSE), however the mechanism(s) by which this occurs is unclear. Some evidence suggests an increase in blood lactate concentration resulting from exercise may be what is driving these changes in corticospinal excitability. The extent of literature examining this effect and whether it is consistent across the literature is unknown.

Enhanced CB1 receptor function in GABAergic neurons mediates hyperexcitability and impaired sensory-driven synchrony of cortical circuits in Fragile X Syndrome model mice.

Electroencephalographic (EEG) recordings in individuals with Fragile X Syndrome (FXS) and the mouse model of FXS ( KO) display cortical hyperexcitability at rest, as well as deficits in sensory-driven cortical network synchrony. A form of circuit hyperexcitability is observed in cortical slices of KO mice as prolonged persistent activity, or Up, states. It is unknown if the circuit mechanisms that cause prolonged Up states contribute to FXS-relevant EEG phenotypes.

Characterization of heparin interactions with Clostridioides difficile toxins and its potential as anti-CDI therapeutics.

Clostridioides difficile (C. difficile) infection (CDI) is a life-threatening healthcare-associated infection occurring worldwide. C.

Dissipative Landau-Zener tunneling in the crossover regime from weak to strong environment coupling.

Landau-Zener tunneling, which describes the transition in a two-level system during a sweep through an anti-crossing, is a model applicable to a wide range of physical phenomena. Realistic quantum systems are affected by dissipation due to coupling to their environments. An important aspect of understanding such open quantum systems is the relative energy scales of the system itself and the system-environment coupling, which distinguishes the weak- and strong-coupling regimes.