Publications by authors named "J L Geh"
Sequencing-based genetic tests have uncovered a vast array of BRCA2 sequence variants. Owing to limited clinical, familial and epidemiological data, thousands of variants are considered to be variants of uncertain significance (VUS). Here we have utilized CRISPR-Cas9-based saturation genome editing in a humanized mouse embryonic stem cell line to determine the functional effect of VUS.
View Article and Find Full Text PDFImmunotherapies, including checkpoint inhibitor antibodies, have precipitated significant improvements in clinical outcomes for melanoma. However, approximately half of patients do not benefit from approved treatments. Additionally, apart from Tebentafusp, which is approved for the treatment of uveal melanoma, there is a lack of immunotherapies directly focused on melanoma cells.
View Article and Find Full Text PDFArticle Synopsis
- Despite advancements in immunotherapies for melanoma, many patients still don't benefit due to current treatments mainly targeting T-cells rather than the more prevalent macrophages in the tumor environment.
- Macrophages have a dual role: they can activate the immune response and kill cancer cells, but they can also aid in tumor growth and spread depending on their interaction with the tumor microenvironment.
- A thorough understanding of macrophages' roles and interactions in melanoma, along with novel therapies aimed at them, is crucial for enhancing treatment outcomes for melanoma patients.
Background: The Evaluation of Groin Lymphadenectomy Extent for Melanoma (EAGLE FM) study sought to address the question of whether to perform inguinal (IL) or ilio-inguinal lymphadenectomy (I-IL) for patients with inguinal nodal metastatic melanoma who have no clinical or imaging evidence of pelvic disease. Primary outcome measure was disease-free survival at 5 years, and secondary endpoints included lymphoedema.
Methods: EAGLE FM was designed to recruit 634 patients but closed with 88 patients randomised because of slow recruitment and changes in melanoma management.