Publications by authors named "J L Freudenheim"
Article Synopsis
- Alcohol consumption is linked to an increased risk of female breast cancer, making it important to understand how cessation impacts this risk.
- A recent meta-analysis found that women who stop drinking may have a reduced risk of estrogen receptor positive (ER+) breast cancer (RR=0.88), while there is no significant risk reduction for estrogen receptor negative (ER-) breast cancer (RR=1.23).
- The study suggests that quitting alcohol may lower the risk of developing ER+ breast cancer, but more research is needed to explore how long cessation effects last.
Article Synopsis
- The American Cancer Society suggests that doctors should talk to women about endometrial cancer risks when they reach menopause, but more younger women under 50 are being diagnosed.
- A study looked at nearly 14,000 women with endometrial cancer and found that factors like body weight and diabetes increase the risk for both younger and older women.
- Educating women about these risk factors could help reduce the number of cases, as many endometrial cancer cases in both age groups are linked to these factors.
Background: There are few studies of social support and other social determinants of health after breast cancer diagnosis and their associations with mortality; results have been inconclusive. Further, it is not known if observed associations are specific to women with breast cancer diagnosis or if associations would be similar among healthy women.
Methods: Women with incident, pathologically confirmed invasive breast cancer, stage I-IV (n = 1012), and healthy frequency age-matched participants (n = 2036) answered a social support questionnaire in prospective follow-up of a population-based case-control study, the Western New York Exposures and Breast Cancer Study.
Lung cancer exhibits sex-biased molecular characteristics and epidemiological trends, suggesting a need for sex-specific approaches to understanding its etiology and treatment. DNA methylation alterations play critical roles in lung carcinogenesis and may serve as valuable biomarkers for precision medicine strategies. We employed the Infinium MethylationEPIC array to identify autosomal sex-related differentially methylated CpG sites (DM-CpGs) in lung epithelium of healthy individuals (32 females and 37 males) while controlling for age, BMI, and tobacco use.
View Article and Find Full Text PDFBackground: The incidence rates of endometrial cancer are increasing, which may partly be explained by the rising prevalence of obesity, an established risk factor for endometrial cancer. Hypertension, another component of metabolic syndrome, is also increasing in prevalence, and emerging evidence suggests that it may be associated with the development of certain cancers. The role of hypertension independent of other components of metabolic syndrome in the etiology of endometrial cancer remains unclear.
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