Publications by authors named "J L Finlay"
Whereas terminally exhausted T (Tex_term) cells retain anti-tumor cytotoxic functions, the frequencies of stem-like progenitor-exhausted T (Tex_prog) cells better reflect immunotherapeutic responsivity. Here, we examined the intratumoral cellular interactions that govern the transition to terminal T cell exhaustion. We defined a metric reflecting the intratumoral progenitor exhaustion-to-terminal exhaustion ratio (PETER), which decreased with tumor progression in solid cancers.
View Article and Find Full Text PDFRecent developments in olfactory neuroblastoma research.
Curr Opin Otolaryngol Head Neck Surg
November 2024
Article Synopsis
- Olfactory neuroblastoma (ONB) is a rare cancer type from olfactory nerve cells, and a recent review focuses on its diagnosis and treatment challenges.
- New research highlights advancements in genomic profiling and the use of targeted therapies, such as somatostatin analogs and PD-L1 inhibitors, along with insights from genetically engineered mouse models.
- These advancements aim to improve diagnosis and personalize treatment for ONB, potentially enhancing patient outcomes through better imaging, targeted therapies, and collaborative research efforts.
Patient-derived organoid model of olfactory ensheathing cell tumor.
Int Forum Allergy Rhinol
September 2024
We developed a culture model of a human olfactory ensheathing cell tumor. Cultured organoids resemble normal ensheathing cells. Assays suggest that this model provides a tool for studying the roles of these glial cells in the maintenance of the peripheral olfactory system.
View Article and Find Full Text PDFArticle Synopsis
- Increased access to genomic profiling in pediatric cancer has improved the identification of genetic variations linked to cancer risk, particularly highlighting Noonan syndrome (NS) and its connection to gliomas and glioneuronal tumors.
- In a study of 314 pediatric cancer patients, 1.3% were found to have germline variants associated with NS, with a significant portion showing these variants linked to glioma diagnoses.
- The research not only confirmed existing associations but also led to the discovery of NS in previously undiagnosed patients, underscoring the value of genomic profiling in recognizing complex genetic conditions related to cancer.