Importance: Children born very preterm are at risk for long-term neurodevelopmental sequelae. Prophylactic high-dose recombinant human erythropoietin (rhEpo) shortly after birth has not been shown to improve cognitive, motor, and behavioral development at 2 and 5 years.
Objective: To investigate whether early high-dose rhEpo is associated with better executive functions and processing speed-late-maturing cognitive functions-in school-aged children born very preterm.
Purpose: To investigate the long-term effects of high-dose recombinant human erythropoietin (rhEPO) administered during the perinatal period on retinal and visual function in children born extremely or very preterm.
Design: Randomized, double-blind clinical trial follow-up plus cohort study.
Methods: Setting: Department of Ophthalmology, University Hospital Zurich, Zurich, Switzerland.
Purpose: To study the long-term effects of perinatal high-dose recombinant human erythropoietin (rhEPO) on macular structural and vascular development in preterm children.
Design: Randomized, double-blind clinical trial follow-up plus cohort study.
Methods: Setting: Department of Ophthalmology, University Hospital Zurich, Zurich, Switzerland.