Publications by authors named "J L Faivre"
Purpose: Patients with oligometastasis may have prolonged survival with multisite stereotactic ablative radiation therapy (SABR). Evidence to support this paradigm is scarce in squamous cell carcinoma of the head and neck (HNSCC). The multicenter open-label randomized GORTEC 2014-04 (NCT03070366) phase 2 study assesses survival without definitive quality of life (QoL) deterioration of omitting upfront chemotherapy in oligometastatic patients with HNSCC using SABR alone, in the French Head and Neck Intergroup.
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- The study aimed to assess the safety and effectiveness of a specific radiation treatment for cervical lymph node cancers in older, frail patients, using a hypofractionated approach.
- A total of 43 patients were analyzed, primarily males with a median age of 83, receiving varying degrees of acute side effects from the treatment, with a majority experiencing radiodermatitis and some needing enteral nutrition.
- After treatment, about 26% of patients had a complete response to the radiation at a median follow-up of 9.2 months, with no severe long-term toxicity reported after three months.
Introduction: The delineation of organs-at-risk and lymph node areas is a crucial step in radiotherapy, but it is time-consuming and associated with substantial user-dependent variability in contouring. Artificial intelligence (AI) appears to be the solution to facilitate and standardize this work. The objective of this study is to compare eight available AI software programs in terms of technical aspects and accuracy for contouring organs-at-risk and lymph node areas with current international contouring recommendations.
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- - Patients with bone metastasis often undergo palliative radiotherapy, with about 20% needing reirradiation to manage symptoms or control local progression of cancer lesions.
- - Around two-thirds of patients experience pain relief from bone reirradiation, but spinal cord damage presents a risk, particularly with cumulative doses over 50 Gy.
- - Effective reirradiation requires careful planning, a multidisciplinary team approach, assessing alternative treatment options, and ensuring that patients are monitored closely after the procedure.
Background: Radiation-induced nausea and vomiting have mutiple clinical consequences: delay or refusal of irradiation (decreased antineoplastic efficacy of irradiation), altered quality of life, dehydration, malnutrition, interruption of treatment, decompensation of comorbidities and aspiration. These guidelines aim at defining good clinical practices for management of radiation-induced nausea and vomiting (RINV).
Methods: AFSOS, SFRO, SFH, SFNEP, SFCE and GFRP applied an expert consensus methodology to propose updated guidelines.