Publications by authors named "J L Ebenau"
Introduction: We investigated changes in self- and study partner-reported self-perceived cognitive decline in relation to amyloid pathology and clinical progression, in a sample of cognitively normal individuals.
Methods: A total of 404 participants (63 ± 9 years, 44% female) and their study partners completed the Cognitive Change Index (CCI) yearly (0.7-6.
Cerebral blood flow, amyloid burden, and cognition in cognitively normal individuals.
Eur J Nucl Med Mol Imaging
January 2023
Purpose: The role of cerebral blood flow (CBF) in the early stages of Alzheimer's disease is complex and largely unknown. We investigated cross-sectional and longitudinal associations between CBF, amyloid burden, and cognition, in cognitively normal individuals with subjective cognitive decline (SCD).
Methods: We included 187 cognitively normal individuals with SCD from the SCIENCe project (65 ± 8 years, 39% F, MMSE 29 ± 1).
Background: Biomarkers for amyloid, tau, and neurodegeneration (ATN) have predictive value for clinical progression, but it is not clear how individuals move through these stages. We examined changes in ATN profiles over time, and investigated determinants of change in A status, in a sample of cognitively normal individuals presenting with subjective cognitive decline (SCD).
Methods: We included 92 individuals with SCD from the SCIENCe project with [F]florbetapir PET (A) available at two time points (65 ± 8y, 42% female, MMSE 29 ± 1, follow-up 2.
Article Synopsis
- The study investigates the sleep issues faced by memory clinic patients with subjective cognitive decline (SCD) and how these problems relate to cognition, mental health, and biomarkers.
- Out of 308 subjects, 64% reported sleep problems, with 35% indicating sleep apnea and 53% suffering from poor sleep quality.
- The findings suggest that enhancing sleep quality could be a potential treatment avenue for alleviating cognitive complaints in SCD patients, as those with sleep problems showed higher levels of depression and anxiety.
Introduction: Empirical studies on effective communication for amyloid disclosure in mild cognitive impairment (MCI) are lacking. We aimed to study the impact of six communication strategies.
Method: We performed a randomized controlled trial with seven randomly assigned, video-vignette conditions: six emphasizing a communication strategy and one basic condition.