Publications by authors named "J L Earls"
Background: Visual assessment of coronary CT angiography (CCTA) is time-consuming, influenced by reader experience and prone to interobserver variability. This study evaluated a novel algorithm for coronary stenosis quantification (atherosclerosis imaging quantitative CT, AI-QCT).
Methods: The study included 208 patients with suspected coronary artery disease (CAD) undergoing CCTA in Perfusion Imaging and CT Coronary Angiography With Invasive Coronary Angiography-1.
Background: While immune checkpoint inhibitor (ICI) therapies can significantly improve outcomes for patients with recurrent/metastatic head and neck squamous cell carcinoma (RM-HNSCC), only about 15-20% benefit from such treatments. Clinical tests that guide the use of ICIs are therefore critically needed. OncoPrism-HNSCC was developed to address this need.
View Article and Find Full Text PDFBackground: Despite advances in cancer care and detection, >65% of patients with squamous cell cancer of the head and neck (HNSCC) will develop recurrent and/or metastatic disease. The prognosis for these patients is poor with a 5-year overall survival of 39%. Recent treatment advances in immunotherapy, including immune checkpoint inhibitors like pembrolizumab and nivolumab, have resulted in clinical benefit in a subset of patients.
View Article and Find Full Text PDFAims: To investigate the location-specific prognostic significance of plaque burden, diameter stenosis, and plaque morphology.
Methods And Results: Patients without a documented cardiac history that underwent coronary computed tomography angiography (CCTA) for suspected coronary artery disease were included. Percentage atheroma volume (PAV), maximum diameter stenosis, and plaque morphology were assessed and classified into proximal, mid, or distal segments of the coronary tree.
Article Synopsis
- The study examines the long-term effects of coronary artery disease (CAD) polygenic risk scores (PRS) on plaque progression and high-risk plaque features over time.
- It found that patients with higher CAD PRS experienced significantly greater plaque volume at baseline and continued to show increased plaque progression over a decade.
- Results indicate that CAD PRS is a valuable tool for predicting future plaque progression and risk of high-risk plaque in patients with suspected CAD.