Impact of new cyclooxygenase 2 inhibitors on human cytomegalovirus replication in vitro.

Background: Human cytomegalovirus (HCMV) is involved in complications on immunocompromised patients. Current therapeutics are associated with several drawbacks, such as nephrotoxicity.

Purpose: As HCMV infection affects inflammation pathways, especially prostaglandin E2 (PGE2) production via cyclooxygenase 2 enzyme (COX-2), we designed 2'-hydroxychalcone compounds to inhibit human cytomegalovirus.

Alternative to animal experimentation in pharmacology teaching: Development and validation of an equivalent digital learning tool.

Regarding animal experiments in pharmacology teaching, ethical considerations led us to examine an alternative approach to the use of living animals. This study aimed to assess whether digital tools could replace live animal experiments in terms of motivation and knowledge acquisition. The study was carried out with students enrolled in the 5th year of the industry/research stream at the Faculty of Pharmacy of the University of Limoges.

Chemical composition and biological potential of Boiss. & Reut. essential oil.

The fresh aerial parts of Boiss. & Reut. (syn.

Design and multi-step synthesis of chalcone-polyamine conjugates as potent antiproliferative agents.

The aim of this study is to synthesize chalcone-polyamine conjugates in order to enhance bioavailability and selectivity of chalcone core towards cancer cells, using polyamine-based vectors. 3-hydroxy-3',4,4',5'-tetramethoxychalcone (1) and 3',4,4',5'-tetramethoxychalcone (2) were selected as parent chalcones since they were found to be efficient anti-proliferative agents on various cancer cells. A series of ten chalcone-polyamine conjugates was obtained by reacting carboxychalcones with different polyamine tails.

Antioxidant Flavonoids from Asteriscus maritimus.

One new flavonol glycoside, patuletin-7-Ο-[6-Ο-caffeoyl-2-Ο-[(S)-3-hydroxyisobutanoyl]glucopyranoside] (astermaritimoside) (1) and four known flavonoids, patuletin-7-Ο-β-[-6-Ο-[(S)-3-hydroxyisobutanoyl]glucopyranoside] (2), patuletin-7-Ο-[6-Ο-caffeoylglucopyranoside] (3), patuletin-7-Ο-β-D- glucopyranoside (4) and quercetin-3-Ο-β-rutinoside (5) have been isolated from Asteriscus maritinus (L.) Less. Chemical structures were elucidated by mass spectrometric, and ¹H NMR, ¹³C NMR, COSY, HMQC and HMBC spectroscopic techniques.