The prevalence and immune response to coinfection by avian haemosporidians in wild Eurasian blackbirds .

Coinfection of a host by more than 1 parasite is more common than single infection in wild environments and can have differing impacts, although coinfections have relatively rarely been quantified. Host immune responses to coinfection can contribute to infection costs but are often harder to predict than those associated with single infection, due to the influence of within-host parasite–parasite interactions on infection virulence. To first quantify coinfection in a common bird species, and then to test for immune-related impacts of coinfection, we investigated the prevalence and immune response to avian haemosporidian (genera: , and ) coinfection in wild blackbirds.

Building an open-source community to enhance autonomic nervous system signal analysis: DBDP-autonomic.

Smartphones and wearable sensors offer an unprecedented ability to collect peripheral psychophysiological signals across diverse timescales, settings, populations, and modalities. However, open-source software development has yet to keep pace with rapid advancements in hardware technology and availability, creating an analytical barrier that limits the scientific usefulness of acquired data. We propose a community-driven, open-source peripheral psychophysiological signal pre-processing and analysis software framework that could advance biobehavioral health by enabling more robust, transparent, and reproducible inferences involving autonomic nervous system data.

Community science as a potential tool to monitor animal demography and human-animal interactions.

Community science can provide crucial insights into population dynamics and demography. To date, its effectiveness for understanding human-wildlife interactions has not been tested. This is vital for designing effective wildlife management plans.

Outcomes of a Population-Based Congenital Cytomegalovirus Screening Program.

Importance: Detection of congenital cytomegalovirus (cCMV) infection has previously relied on targeted screening programs or clinical recognition; however, these approaches miss most cCMV-infected newborns and fail to identify those infants who are asymptomatic at birth but at risk for late-onset sensorineural hearing loss.

Objective: To determine the feasibility of using routinely collected newborn dried blood spots (DBS) in a population-based cCMV screen to identify infants at risk for hearing loss and describe outcomes of infants screened.

Design, Setting, And Participants: This diagnostic study of a population-based screening program in Ontario, Canada, took place from July 29, 2019, to July 31, 2023.

Time to weight plateau with tirzepatide treatment in the SURMOUNT-1 and SURMOUNT-4 clinical trials.

The rate of weight reduction during obesity treatment declines over time and eventually reaches a weight plateau. We investigated factors associated with time to weight plateau (TTWP) in tirzepatide-treated participants with obesity or overweight in a post-hoc analysis of SURMOUNT-1 and SURMOUNT-4 trials. Participants adherent to tirzepatide treatment and achieving ≥5% weight loss by primary endpoint (week 72 SURMOUNT-1; week 88 SURMOUNT-4) were included.