Publications by authors named "J L Domingo"

Meat and meat products are vital sources of essential nutrients for human health and development. However, an excessive or inappropriate consumption can pose significant health risks. In 2015, the International Agency for Research on Cancer (IARC) classified red meat as "probably carcinogenic to humans" and processed meat as "carcinogenic to humans", yet the role of environmental contaminants in these products was not addressed.

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Understanding the role of transcription and transcription factors (TFs) in cellular identity and disease, such as cancer, is essential. However, comprehensive data resources for cell line-specific TF-to-target gene annotations are currently limited. To address this, we employed a straightforward method to define regulons that capture the cell-specific aspects of TF binding and transcript expression levels.

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Prediabetes disproportionately affects racial and ethnic minority groups in Hawai'i. The National Diabetes Prevention Program lifestyle change program (National DPP LCP) decreases the risk of developing diabetes. However, enrolling and retaining participants is a challenge for program providers.

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Recently, an association between dysbiosis of the gut microbiota (GMB) and the development of several diseases, such as Alzheimer's disease (AD), has been proposed. Dysbiosis involves changes in microbial diversity influenced by environmental factors, like diet or lifestyle. In this study, we investigated the role of GMB parameters in Spanish AD patients, assessing the impact of adherence to the Mediterranean lifestyle (ML), as well as to characterize these parameters in relation to neuropsychological, neuropsychiatric, emotional, and functionality parameters.

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Article Synopsis
  • Human exposure to toxic elements like arsenic, cadmium, lead, and mercury can lead to serious health problems, primarily through dietary intake.
  • Recent studies have focused on the levels of these toxic elements in food, with China and Spain being the most researched countries; in Spain, Catalonia has conducted the most studies on trace elements in food.
  • The review found a decrease in estimated dietary intakes of these toxic elements over time, attributed to lower concentrations in food and changes in dietary habits, with fish and seafood containing the highest levels; however, safety thresholds set by the EFSA were not exceeded by most adult groups.
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