Publications by authors named "J L Denis"
Article Synopsis
- The study aimed to standardize qPCR procedures for diagnosing Mucorales by examining factors that influence DNA extraction and PCR amplification efficiency.
- Two panels of samples were distributed to 26 laboratories, and results showed that using larger serum volumes for DNA extraction and larger input volumes for PCR significantly improved detection sensitivity.
- Findings highlight the importance of optimizing laboratory techniques to enhance diagnosis of Mucormycosis, a serious fungal infection, which is critical for timely treatment in vulnerable patients.
Article Synopsis
- Grade 3 meningiomas are rare and linked to high morbidity and mortality, but the effects of surgical resection and radiation therapy on patient outcomes are still debated.
- A study was conducted on 65 patients with de novo anaplastic meningiomas, revealing a median progression-free survival of 23 months and an overall survival of 2 years, with certain treatments showing significant impact.
- The combination of gross-total resection and adjuvant radiotherapy improved progression-free survival, while tumor grade and age at diagnosis also affected outcomes.
Intestinal mucins play a crucial role in the mucosal barrier, serving as the body's initial defense against microorganisms. However, how the host regulates the secretion and glycosylation of these mucins in response to bacterial invasion remains unclear. Our study demonstrates that when exposed to (), a gut pathobiont, the host mucosa promptly adjusts the behavior of specialized goblet cells (GCs) located in the middle of the crypts.
View Article and Find Full Text PDFArticle Synopsis
- Early pregnancy Zika virus (ZIKV) infection can cause serious brain damage in fetuses, resulting in conditions like microcephaly, though the exact mechanisms of this damage are still not fully understood.
- A study using cynomolgus macaque fetuses showed that ZIKV was transmitted from infected fetuses to their mothers, leading to detectable viral levels in blood, brain, and placenta, along with signs of brain size reduction in the infected fetuses.
- Despite persistent viral genetic material in tissues, the immune response helped clear much of the virus before the delivery, indicating that while short-term brain injury occurs, the body can partially control the infection.