Association of statins use and genetic susceptibility with incidence of Alzheimer's disease.

Background: The effect of statins use on the incidence of Alzheimer's disease (AD) is still under debate, and it could be modified by a series of factors.

Objectives: We aimed to examine the association of statins use with the risk of cognitive impairment and AD, and assess the moderating roles of genetic susceptibility and other individual-related factors.

Design: A longitudinal study was conducted from the UK Biobank where individuals completed baseline surveys (2006-2010) and were followed (mean follow-up period: 9 years).

Formosanin C induces autophagy-mediated cell death in hepatocellular carcinoma through activating DUSP1/AMPK/ULK1/Beclin1 signaling pathway.

Background: Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers and is associated with poor survival. Formosanin C (FC) is a diosgenin glycoside extracted from Paris polyphylla. Therapeutic effects of FC against HCC malignancies remain unclear.

Utilization of municipal solid waste incineration fly ash with different pretreatments with gold tailings and coal fly ash for environmentally friendly geopolymers.

Municipal solid waste incineration fly ash (MSWIFA) is considered a hazardous solid waste, traditionally disposed by solidified landfill methods. However, solidified landfills present challenges with leaching heavy metals, polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs). To address this issue, this study examined two pretreatment methods for MSWIFA: sintering at 850℃ for 30 min and washing with three water baths (20 min each) at a 3:1 liquid-solid ratio.

Identification of the Granule-Bound Starch Synthase (GBSS) Genes Involved in Amylose Biosynthesis in Tartary Buckwheat ( (L.) Gaertn.).

Tartary buckwheat is a nutrient-rich pseudo-cereal whose starch contents, including amylose and amylopectin contents, and their properties hold significant importance for enhancing yield and quality. The granule-bound starch synthase (GBSS) is a key enzyme responsible for the synthesis of amylose, directly determining the amylose content and amylose-to-amylopectin ratio in crops. Although one has already been cloned, the genes at the genome-wide level have not yet been fully assessed and thoroughly analyzed in Tartary buckwheat.

MSCD-YOLO: A Lightweight Dense Pedestrian Detection Model with Finer-Grained Feature Information Interaction.

Pedestrian detection is widely used in real-time surveillance, urban traffic, and other fields. As a crucial direction in pedestrian detection, dense pedestrian detection still faces many unresolved challenges. Existing methods suffer from low detection accuracy, high miss rates, large model parameters, and poor robustness.