Publications by authors named "J L Demory"
Article Synopsis
- Myeloproliferative neoplasms (MPNs) are rare in individuals under 25, and a study examined 444 such patients over a median follow-up of 9.7 years across 38 centers globally.
- The study found that 11.1% had a history of thrombosis, with higher risks associated with the JAK2V617F mutation and hyperviscosity symptoms, while new thrombotic and hemorrhagic events occurred at significant rates.
- It highlighted that disease transformation, particularly to myelofibrosis, was common, with splenomegaly identified as a new risk factor, indicating a need for updated management guidelines for young MPN patients.
Benefits and pitfalls of pegylated interferon-α2a therapy in patients with myeloproliferative neoplasm-associated myelofibrosis: a French Intergroup of Myeloproliferative neoplasms (FIM) study.
Haematologica
March 2018
Article Synopsis
- The study focuses on the long-term outcomes of 62 patients with myeloproliferative neoplasm-associated myelofibrosis treated with pegylated interferon-α2a, highlighting improvements in survival rates and mutational patterns.
- The median follow-up was 58 months, and nearly half of the patients were alive at the time of analysis, with those receiving pegylated interferon showing better survival compared to historical cohorts.
- Next-generation sequencing revealed that many patients had non-driver mutations, with the presence of additional mutations linked to poorer survival, reinforcing the potential benefits of pegylated interferon in this patient population.
In a quantum network based on atoms and photons, a single atom should control the photon state and, reciprocally, a single photon should allow the coherent manipulation of the atom. Both operations require controlling the atom environment and developing efficient atom-photon interfaces, for instance by coupling the natural or artificial atom to cavities. So far, much attention has been drown on manipulating the light field with atomic transitions, recently at the few-photon limit.
View Article and Find Full Text PDFBright single photon sources have recently been obtained by inserting solid-state emitters in microcavities. Accelerating the spontaneous emission via the Purcell effect allows both high brightness and increased operation frequency. However, achieving Purcell enhancement is technologically demanding because the emitter resonance must match the cavity resonance.
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