Publications by authors named "J L Damasceno"
Antibacterial, antibiofilm, and antivirulence potential of the main diterpenes from Copaifera spp. oleoresins against multidrug-resistant bacteria.
Naunyn Schmiedebergs Arch Pharmacol
September 2024
To evaluate the antibacterial, antibiofilm and antivirulence potential of the main diterpenes from Copaifera spp. oleoresins against multidrug-resistant (MDR) bacteria. Antimicrobial assays included determination of the Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC), Minimum Inhibitory Concentration of Biofilm (MICB), as well as synergistic and antivirulence assays for eight diterpenes against MDR.
View Article and Find Full Text PDFAncestral aneuploidy and stable chromosomal duplication resulting in differential genome structure and gene expression control in trypanosomatid parasites.
Genome Res
April 2024
Aneuploidy is widely observed in both unicellular and multicellular eukaryotes, usually associated with adaptation to stress conditions. Chromosomal duplication stability is a tradeoff between the fitness cost of having unbalanced gene copies and the potential fitness gained from increased dosage of specific advantageous genes. Trypanosomatids, a family of protozoans that include species that cause neglected tropical diseases, are a relevant group to study aneuploidies.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to investigate the prevalence of piroplasmids in dogs and ticks in Teresópolis, Brazil, assessing their clinical and blood profiles through a combination of blood tests and PCR methods.
- - Out of 400 dogs examined between 2020 and 2021, 2.3% tested positive for piroplasmids, with notable associated health issues including bleeding, jaundice, and specific blood cell irregularities; Rangelia vitalii was the primary infection found.
- - The findings highlight that while two species of piroplasmids can infect dogs in the region, Rangelia vitalii is the most common in the studied population, indicating the need for awareness and potential treatment options
Background: Universal adhesive systems used for restorative clinical procedures are like orthodontics and may be a viable option. This study evaluated the effectiveness of universal adhesive systems in enhancing the durability of the shear bond strength (SBS) and adhesive remnant index (ARI) of orthodontic brackets to enamel.
Material And Methods: 100 bovine incisors were divided into five groups (n=20), according to the applied adhesive systems: Primer Transbond XT; Ambar; Ambar Universal; Single Bond Universal; Adper Single Bond 2.
Article Synopsis
- * In African trypanosomes, a specific process called targeted recombination helps them evade host immunity by activating one out of many silent variant genes, with unclear mechanisms behind it.
- * The enzyme RAD51 interacts with RNA-DNA hybrids and is crucial for repairing DNA breaks, with mutations in RAD51 affecting the abundance of these hybrids and disrupting the repair related to immune evasion strategies.