Targeted nanoliposomes to improve enzyme replacement therapy of Fabry disease.

The central nervous system represents a major target tissue for therapeutic approach of numerous lysosomal storage disorders. Fabry disease arises from the lack or dysfunction of the lysosomal alpha-galactosidase A (GLA) enzyme, resulting in substrate accumulation and multisystemic clinical manifestations. Current enzyme replacement therapies (ERTs) face limited effectiveness due to poor enzyme biodistribution in target tissues and inability to reach the brain.

Cyberbullying Experiences: Whether and How Do the Need for Popularity and Emotional Intelligence Dimensions Affect Them?

The need for popularity and emotional intelligence (EI) have been shown to be relevant factors in relation to aggressive behavior, including cyberbullying. However, the need for popularity and EI have not yet been explored together in relation to cyberbullying victimization and perpetration in adolescence. This research attempts to examine whether the need for popularity was a relevant mediating variable in the link between EI dimensions and both cybervictimization and cyberbullying perpetration, and to identify possible gender differences.

Entanglement Autodistillation from Particle Decays.

Particle decays do not constitute a spin "measurement" in the quantum-mechanical sense but still modify the spin state, in particular, for an entangled system. We show that for a spin-entangled pair of particles the entanglement of the system can increase after the decay of one particle. This unique phenomenon has no equivalent for stable particles and could be observable in top pair production at a high-energy polarized e^{+}e^{-} collider.

How Insect Exocrine Glands Work.

Exocrine glands release a secretion to the body surface or into a lumen and are likely to be found in all insect taxa. Their secretions are diverse, serving many physiological, behavioral, and defensive functions. Much research has characterized gland structure and secretion identity and function, but little research has attempted to understand how these glands work to release secretion amounts in a timescale appropriate to function: How are some (e.

Histone Acetyl Transferase 1 Is Overexpressed in Poor Prognosis, High-grade Meningeal and Glial Brain Cancers: Immunohistochemical and Aptahistochemical Study.

Primary malignancies of the central nervous system account for 2% of all cancers in adults and almost 15% in children under 15 years of age. The prognosis of brain anaplastic cancers and glioblastomas remains extremely poor, with devastating survival expectative, and new molecular markers and therapeutic targets are essential. Epigenetic changes constitute an extensive field for the development of new diagnostic and therapeutic strategies.