Publications by authors named "J L Carballo"
The cell cycle, essential for growth, reproduction, and genetic stability, is regulated by a complex network of cyclins, Cyclin-Dependent Kinases (CDKs), phosphatases, and checkpoints that ensure accurate cell division. CDKs and phosphatases are crucial for controlling cell cycle progression, with CDKs promoting it and phosphatases counteracting their activity to maintain balance. The nucleolus, as a biomolecular condensate, plays a key regulatory role by serving as a hub for ribosome biogenesis and the sequestration and release of various cell cycle regulators.
View Article and Find Full Text PDFTransdiagnostic factors predicting prescription opioid-use disorder severity: A 12-month prospective study in patients on long-term opioid therapy for chronic pain.
Drug Alcohol Depend
November 2024
Article Synopsis
- Research indicates that certain psychological factors, such as anticipatory pleasure and cognitive control, significantly impact the severity of Prescription Opioid-Use Disorder (POUD) in chronic pain patients on long-term opioid therapy.
- A study involving 67 patients revealed that the inability to experience pleasure, poor emotional regulation, and sleep quality were strong predictors of increased POUD severity over time.
- The findings suggest that targeting these psychological factors could help in identifying patients at risk and improving treatment strategies for those dealing with chronic pain and opioid use.
Tolerance, interdose withdrawal symptoms, and craving predict prescription opioid-use disorder severity in chronic pain patients: A three-wave prospective study.
Psychiatry Res
December 2024
The DSM-5-TR diagnostic criteria for Prescription Opioid-Use Disorder (POUD) have undergone significant changes when using opioids medically supervised. However, there is a lack of research supporting these changes. This prospective study aimed to analyze the influence of tolerance, withdrawal symptoms, and craving on the severity of POUD in chronic pain population on long-term opioid therapy.
View Article and Find Full Text PDFObjectives: Good sleep during adolescence is crucial for maintaining physical and psychological health; however, sleep disturbance during this period may contribute to health risks, such as substance use. This study aimed to identify the latent sleep patterns across male and female adolescents, and their association with drug use.
Method: A cross-sectional study was conducted involving 1391 high school students (aged 15-17; 56.