Publications by authors named "J L Capablo"
Article Synopsis
- ALS is a neurodegenerative disorder with varying survival rates, making it critical to identify biomarkers that can help in diagnosis and prognosis; one such biomarker is mitochondrial aconitase (Aco2), which is sensitive to oxidative damage.
- A study measured Aco2 activity in blood platelets from ALS patients compared to controls, finding significantly lower levels in ALS patients, which correlated with their clinical prognosis.
- The results suggest that Aco2 activity might be a valuable indicator of ALS progression, with higher activity associated with longer survival and earlier disease onset.
Background: Accumulation of galactosphingolipids is a general characteristic of Fabry disease, a lysosomal storage disorder caused by the deficient activity of α-galactosidase A encoded by the GLA gene. Although many polymorphic GLA haplotypes have been described, it is still unclear whether some of these variants are causative of disease symptoms. We report the study of an inheritance of a complex intronic haplotype (CIH) (c.
View Article and Find Full Text PDFBlood platelets have been widely proposed as biomarkers in studies of mitochondrial function and aging-related and neurodegenerative diseases. Defects in mitochondrial function were found not only in the substantia nigra of Parkinson's disease patients but also in their blood platelets. Similarly, it has also been described in the blood platelet mitochondria of Alzheimer's disease patients.
View Article and Find Full Text PDFIntroduction: The objective of this retrospective study was to describe the short- and long-term patterns of IVIg use, safety, and response to treatment in patients with chronic inflammatory demyelinating polyneuropathy (CIDP).
Methods: Response to therapy was defined as an improvement of ≥ 1 point on the modified Rankin score at short- and mid-term visits. Patient status at long term was classified as remission, stability, or non-responder.