Publications by authors named "J L Cantera"
Lipoarabinomannan (LAM) is a promising target biomarker for diagnosing subclinical and clinical tuberculosis (TB). Urine LAM (uLAM) testing using rapid diagnostic tests (RDTs) has been approved for people living with HIV (PLWH), however there is limited data regarding uLAM levels in HIV-negative (HIV-ve) adults with clinical TB. We conducted a clinical study of adults presenting with clinical TB-related symptoms at the National Lung Hospital in Hanoi, Vietnam.
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- Development of a non-sputum test for tuberculosis (TB) using lipoarabinomannan (LAM) biomarker concentrations in urine and blood samples was studied to improve diagnostic accuracy, particularly for individuals with and without HIV.
- A diagnostic study in South Africa evaluated LAM levels in urine, plasma, and serum among adults with TB symptoms, finding urine LAM sensitivity of 62% and specificity of 99% using the S4-20 assay; higher sensitivity was observed in HIV-negative participants.
- The findings suggest that while non-sputum specimens can detect LAM for TB diagnosis, improving analyte concentration or signal amplification may be necessary to meet
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- Huntington disease (HD) is a neurodegenerative disorder causing cognitive and motor decline, with current therapies lacking effectiveness in managing these issues.
- A new tablet-based rhythmic drumming app (HD-DRUM) was developed using an integrated knowledge translation (IKT) framework, focusing on user engagement to address the accessibility needs of individuals with HD and track their progress.
- The development process included a survey to pinpoint user challenges, usability tests for tablet interactions, and adjustments to ensure the app features easy navigation and visual clarity to accommodate cognitive and motor impairments.
We evaluated the performance of rapid antigen (RAg) and antibody (RAb) microfluidic diagnostics with serial sampling of 71 participants at 6 visits over 2 months following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Rapid tests showed strong agreement with laboratory references (κAg = 81.0%; κAb = 87.
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