Publications by authors named "J L Cain"
In response to rising levels of burnout and stress among pharmacy faculty, there is a growing call to reassess traditional approaches to productivity and well-being within the Academy. We introduce a "slower" approach to faculty work, one that advocates for a deliberate focus on quality over quantity and promoting sustainable practices that prioritize meaningful contributions and personal well-being. The aim of this commentary is to encourage pharmacy faculty to embrace a slow mindset while maintaining the ability to contribute meaningfully to the lives of their students, patients, colleagues, and the profession of pharmacy.
View Article and Find Full Text PDFNucleotide sequences along a gene provide instructions to transcriptional and cotranscriptional machinery allowing genome expansion into the transcriptome. Nucleotide sequence can often be shared between two genes and in some occurrences, a gene is located completely within a different gene; these are known as host/nested gene pairs. In these instances, if both genes are transcribed, overlap can result in a transcriptional crosstalk where genes regulate each other.
View Article and Find Full Text PDFSmall cell lung cancer (SCLC) is an aggressive neuroendocrine tumor characterized by a high metastatic potential with an overall survival rate of ~5%. The transcription factor signal transducer and activator of transcription 3 (STAT3) is overexpressed by >50% of tumors, including SCLC, but its role in SCLC development and metastasis is unclear. Here, we show that, while STAT3 deletion restricts primary tumor growth, it paradoxically enhances metastatic spread by promoting immune evasion.
View Article and Find Full Text PDFInitial Experience with Lecanemab and Lessons Learned in 71 Patients in a Regional Medical Center.
J Prev Alzheimers Dis
November 2024
Article Synopsis
- The FDA approved lecanemab (Leqembi®) on July 6, 2023, for treating mild cognitive impairment or mild dementia caused by Alzheimer's disease, with early experiences shared from a regional medical center.
- A retrospective study at the Norton Neuroscience Institute Memory Center involved 71 patients, all diagnosed with Alzheimer’s through cerebrospinal fluid biomarkers, most of whom were older, predominantly female, and referred by their primary care providers.
- The study found that 24% of patients experienced amyloid-related imaging abnormalities (ARIA) after treatment, with differences noted between those homozygous and heterozygous for the ApoE4 genotype.
Objective: This study aimed to evaluate the feasibility and perceived value of an instructor-developed ChatGPT-based virtual tutor for third-year Doctor of Pharmacy students in a pharmacy management course. The objectives were to assess faculty time required to develop the tool and analyze student engagement and perception of its educational value.
Methods: The virtual tutor was developed by the instructor and consisted of custom ChatGPT prompts deployed via the course's learning management system.