Publications by authors named "J L Cahill"
Acid-sensing ion channels (ASICs) are typically activated by acidic environments and contribute to nociception and synaptic plasticity. ASIC1a is the most abundant subunit in the central nervous system and forms homomeric channels permeable to Na and Ca , making it a compelling therapeutic target for acidotic pathologies including stroke and traumatic brain injury. However, a complete conformational library of human ASIC1a in its various functional states has yet to be described.
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- - The study investigated a diverse group of 95 enzymes from the N-terminal nucleophile hydrolase superfamily, focusing on their ability to hydrolyze synthetic polyamides like nylon.
- - About 40% of these enzymes demonstrated significant nylon hydrolase activity, comparable to the well-known enzyme NylC, without any clear link between their evolutionary relationships and their hydrolytic capabilities.
- - Researchers identified several enzymes with strong substrate selectivity, especially those that efficiently processed Nylon 6,6, and also analyzed the crystal structure of a specific hydrolase to better understand the factors affecting its activity and selectivity.
Background: Annually, about 4000 US children undergo a tracheostomy procedure to provide a functional, safe airway. In the hospital, qualified staff monitor and address problems, but post-discharge this responsibility shifts entirely to caregivers. The stress and constant demands of caregiving for a child with a tracheostomy with or without ventilator negatively affect caregivers.
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- Many places in the world are facing big problems because of not enough water, which affects farming and water supplies.
- Chia, a new type of crop, is being studied to see if it uses less water than crops like alfalfa, corn, and soybean.
- Research shows that chia uses 13-38% less water and grows better with the water it does use, so planting more chia instead of alfalfa in dry areas could save a lot of water.
Introduction: The incidence of intracranial metastatic disease is increasing worldwide. As a valuable treatment modality, stereotactic radiosurgery requires detailed imaging, and this study evaluated the differences between imaging obtained on the day of treatment compared to historical or referral imaging.
Materials And Methods: A retrospective cohort study was performed, evaluating all the patients presenting with eligible referral imaging in a 13-month period and comparing this imaging to the imaging taken on the day of treatment.