Publications by authors named "J L Bourdon"
The gene encodes several isoforms of elusive biological significance. Here, we show that mice lacking the alternatively spliced (AS) exon, thereby expressing the canonical p53 protein but not isoforms with the AS C-terminus, have unexpectedly lost a male-specific protection against Myc-induced B-cell lymphomas. Lymphomagenesis was delayed in males compared to males, but also compared to and females.
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- Researchers found that changes in a specific part of the p53 gene, called p53β, might be important in causing some types of cancer.
- They discovered a special change (stop-lost variant) in this gene in four families with a history of certain cancers like colorectal, breast, and thyroid cancer.
- This change affects how p53β works and can increase cancer risk, showing that we need to look closely at all parts of the p53 gene to better understand cancer and who might be at risk.
Photocatalysis mediated by low energy light wavelengths has potential to enable safer, sustainable synthetic methods. A phenanthroline-derived ligand bathocupSani, with a large two-photon absorption (TPA) cross section was used to construct a heteroleptic complex [Cu(bathocupSani)(DPEPhos)]BF and a homoleptic complex [Cu(bathocupSani)]BF. The ligand and the respective homoleptic complex with copper exhibit two-photon upconversion with an anti-Stokes shift of 1.
View Article and Find Full Text PDFBackground: There is a lack of consensus in the addiction field as to how to refer to alumni of residential treatment who no longer use substances or who reduce their use. In the literature, this label and broader identity are typically discussed in technical (amount and frequency of use) or social terms (environment and social network changes).
Objective: The current paper seeks to simplify the discussion by focusing on personal labels without complex technical or social considerations.