Publications by authors named "J L Berges"
In patients with cystic fibrosis (CF), repeated cycles of infection and inflammation eventually lead to fatal lung damage. Although diminished mucus clearance can be restored by highly effective CFTR modulator therapy, inflammation and infection often persist. To elucidate the role of the innate immune system in CF etiology, we investigated a CF pig model and compared these results with those for preschool children with CF.
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- Patchy data on litter decomposition in wetlands limits understanding of carbon storage, prompting a global study involving over 180 wetlands across multiple countries and climates.
- The study found that freshwater wetlands and tidal marshes had more organic matter remaining after decay, indicating better potential for carbon preservation in these areas.
- Elevated temperatures positively affect the decomposition of resistant organic matter, with projections suggesting an increase in decay rates by 2050; however, the impact varies by ecosystem type and highlights the need to recognize both local and global factors influencing carbon storage.
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- Macrophages play a crucial role in the effectiveness of the anti-CD19 antibody tafasitamab, which is used to treat certain types of lymphoma.
- The study focuses on the CD47-SIRPα interaction, which can inhibit the macrophages' ability to effectively eliminate tumor cells, and suggests that blocking CD47 may boost tafasitamab's effectiveness.
- Experimental results showed that combining tafasitamab with an anti-CD47 antibody improved phagocytosis of lymphoma cells and resulted in better outcomes in animal models, indicating potential for clinical application.
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- - The study investigated the impact of elexacaftor/tezacaftor/ivacaftor (ETI) on lung health in school-age children (ages 6-11) with cystic fibrosis (CF), specifically looking at lung clearance index (LCI) and lung MRI scores over a year.
- - A total of 107 children participated, showing significant improvements in LCI and MRI scores three months after starting ETI, with better results for both heterozygous and homozygous mutations.
- - The findings suggest that early treatment with ETI can enhance lung function and structure, potentially slowing down lung disease progression in children with CF.
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- The study explores the role of CD101, an immunoglobulin-like glycoprotein, in T lymphocytes and myeloid cells during intestinal diseases like colitis and Salmonella infections.
- CD101 deficiency in regulatory T cells led to worsened intestinal damage in both colitis and Salmonella models, highlighting its importance in mediating immune responses.
- The research reveals that CD101 helps control Salmonella infections through specific immune mechanisms and that its expression in myeloid cells is reduced in inflammatory bowel disease, suggesting a link between CD101 and immune regulation in these conditions.