The relationship between familial factors and youth mental health outcomes in Korean American families: The mediation effects of youth's negative emotionality.

Depressive symptoms are one of the mental health problems among Korean American (KA) youth. Although several studies examined mental distress among KA youth, few have examined the associations between different familial factors, negative emotionality, and depressive symptoms among them, especially using longitudinal data. Drawing on the Triadic Model of Family Process (TMFP), this study examined the longitudinal associations between Korean-specific aspects of familial factors and depressive symptoms among KA youth and the mediation role of negative emotionality in the relationships.

Identifying targetable metabolic dependencies across colorectal cancer progression.

Colorectal cancer (CRC) is a multi-stage process initiated through the formation of a benign adenoma, progressing to an invasive carcinoma and finally metastatic spread. Tumour cells must adapt their metabolism to support the energetic and biosynthetic demands associated with disease progression. As such, targeting cancer cell metabolism is a promising therapeutic avenue in CRC.