Publications by authors named "J L Barnard"
Background: Despite advances in ablation and other therapies for AF, progression of atrial fibrillation (AF) remains a significant clinical problem, associated with worse prognosis and worse treatment outcomes. Upstream therapies targeting inflammatory or antifibrotic mechanisms have been disappointing in preventing AF progression, but more recently genetic and genomic studies in AF suggest novel cellular and metabolic stress targets, supporting prior studies of lifestyle and risk factor modification (LRFM) for AF. However, while obesity is a significant risk factor, weight loss and risk factor modification have not been successfully applied in a US population with AF.
View Article and Find Full Text PDFAlterations in Mitochondrial Function in Pulmonary Vascular Diseases.
Antioxid Redox Signal
December 2024
Alterations of mitochondrial bioenergetics and arginine metabolism are universally present and mechanistically linked to pulmonary arterial hypertension (PAH), but there is little knowledge of arginine metabolism and mitochondrial functions across the different pulmonary hypertension (PH) groups. We hypothesize that abnormalities in mitochondrial functions are present across all PH groups and associated with clinical phenotypes. We test the hypothesis in PH patients and healthy controls from the Pulmonary Vascular Disease Phenomics Program cohort, who had comprehensive clinical phenotyping and follow-up for at least 4 years for death or transplant status.
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- Atrial fibrillation (AF) often recurs after catheter ablation, and the study investigates how changes in the pulmonary vein (PV) structure, highlighted by artificial intelligence (AI), relate to this recurrence.* -
- Two AI models were used to analyze CT images from 809 patients, examining features of primary and secondary PV branches to determine their link to AF recurrence post-ablation.* -
- The findings suggest that morphological features of primary PV branches have a significant association with AF recurrence, indicating potential pathways for improving patient outcomes after ablation.*
Article Synopsis
- Complex oxide thin films are essential for various electronic and optical devices, typically requiring high-quality single crystalline substrates like SrTiO (STO) for growth.
- Recent advancements allow for the transfer of these films as free-standing structures, enabling the integration of complex oxides into other devices and promoting the recycling of the original substrates for cost-effective and sustainable production.
- The study reveals that recycled STO substrates can influence the microstructure and properties of subsequently grown oxide films, potentially enhancing their characteristics, as seen with improved ferromagnetic responses in yttrium iron garnet films when grown on recycled STO compared to pristine substrates.
Genome-wide association studies have identified a locus on chromosome 10q22, where many co-inherited single nucleotide polymorphisms (SNPs) are associated with atrial fibrillation (AF). This study seeks to identify the impact of this locus on gene expression at the transcript isoform level in human left atria and to gain insight into potential causal variants. Bulk RNA sequencing was analyzed to identify myozenin 1 () and synaptopodin 2-like () transcript isoforms and the association of common SNPs in this region with transcript isoform expression levels.
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