Publications by authors named "J L Banales"
Background And Aims: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterised by progressive biliary inflammation and fibrosis, leading to liver cirrhosis and cholangiocarcinoma. GPBAR1 (TGR5) is a G protein-coupled receptor for secondary bile acids. In this study, we have examined the therapeutic potential of BAR501, a selective GPBAR1 agonist in a PSC model.
View Article and Find Full Text PDFBackground: Cholangiocarcinoma (CCA) represents a global health challenge, with rising incidence and mortality rates. This study aimed to elucidate the clinical course and practices of CCA in Latin America.
Methods: This observational cohort study investigated individuals diagnosed with CCA between 2010 and 2023 at five referral centres across Latin America.
Article Synopsis
- Metabolic liver disease is increasingly linked to hepatocellular carcinoma (HCC), but the molecular mechanisms remain poorly understood; this study focuses on DNA methylation's role in HCC associated with metabolic issues.
- The research involved 272 HCC patients and 316 control subjects, revealing 55 DNA methylation markers that effectively distinguished HCC cases from controls, achieving an AUC of 0.79 for accuracy.
- Combining these markers with demographic data improved sensitivity and specificity for identifying patients at risk for metabolic HCC.
Article Synopsis
- Metabolic dysfunction-associated steatotic liver disease (MASLD) is a serious liver condition that includes simple fat buildup in the liver (steatosis) and can progress to more severe forms, like metabolic dysfunction-associated steatohepatitis (MASH) and cirrhosis, affecting over a third of the population.* -
- The causes of MASLD are complex and involve factors like metabolism, environment, genetics, gut microbiota, and dysregulated lipid levels that lead to harmful fat and cell stress.* -
- This review focuses on how lipotoxicity contributes to the development of MASLD, detailing important lipid types and their effects, and exploring potential therapies to improve lipid metabolism and reduce liver damage.*
Aims: Drug export through ABC proteins hinders cancer response to chemotherapy. Here, we have evaluated the relevance of MRP3 (ABCC3) in cholangiocarcinoma (CCA) as a potential target to overcome drug resistance.
Methods: Gene expression was analyzed in silico using the TCGA-CHOL database and experimentally (mRNA and protein) in resected CCA tumors.