Publications by authors named "J L Augy"
Article Synopsis
- Ageing affects immune responses, increasing the risk of infections like COVID-19 in older adults, particularly through factors related to cytotoxic T cells and chronic inflammation.* -
- In a study of 104 patients over 70, severe COVID-19 correlated with higher levels of specific cytokines (like GM-CSF and IL-1β) and changes in CD8 T cell populations, including more terminally differentiated cells and fewer stem cell-like memory cells.* -
- The findings suggest that certain cytokines are key indicators of COVID-19 severity in older patients and emphasizes the need for tailored care approaches based on these immune changes in this age group.*
Article Synopsis
- The study analyzed 20 years of data on severe asthma exacerbation (SAE) admissions in adult patients at 40 ICUs in the greater Paris area to understand trends in patient characteristics, management, and outcomes.
- Admissions for SAE significantly declined over the two decades, dropping from 2.84% of total ICU admissions in 1997-2001 to 1.05% in both 2007-2011 and 2012-2016.
- Although the use of mechanical ventilation remained low, factors like older age and severe symptoms were linked to higher ICU mortality rates, while overall ICU and hospital mortality decreased over the study period.
Background: Despite evidence suggesting a higher risk of barotrauma during COVID-19-related acute respiratory distress syndrome (ARDS) compared to ARDS due to other causes, data are limited about possible associations with patient characteristics, ventilation strategy, and survival.
Methods: This prospective observational multicenter study included consecutive patients with moderate-to-severe COVID-19 ARDS requiring invasive mechanical ventilation and managed at any of 12 centers in France and Belgium between March and December 2020. The primary objective was to determine whether barotrauma was associated with ICU mortality (censored on day 90), and the secondary objective was to identify factors associated with barotrauma.
Background: In-hospital cardiac arrest(IHCA) has received little attention compared with out-of-hospital cardiac arrest.
Aim: To address the paucity of data on IHCA patients, we examined key features, variations in mortality and predictors of death among patients admitted in French intensive care units(ICUs) from 1997 to 2015.
Methods: Using the database of the Collège des Utilisateurs de Bases de données en Réanimation(CUB-Réa) that prospectively collects data from ICUs in the greater Paris area, we determined temporal trends in the incidence of IHCA, patients' outcomes, crude and Simplified Acute Physiology Score(SAPS)-II Standardized mortality and predictors of in-ICU mortality.