Publications by authors named "J L Auffray"

Article Synopsis
  • Tablets provide advantages like easy use, cost-effectiveness, and better stability for delivering biopharmaceuticals, allowing for innovative local administration methods.
  • This study focuses on developing monoclonal antibodies in tablet form while maintaining their biological function, analyzing the effects of different excipients and processing parameters.
  • Results indicate that compressing antibodies at 100 MPa does not harm their binding properties, and the tablets remain stable for 6 months at room temperature, suggesting a promising method for biopharmaceutical delivery.
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Background: The waters surrounding the French Southern Lands are a fishing zone, accessible only by sailing for several days in a region where weather conditions are often difficult. The scientific bases of the region have medical staff whose services can be called upon if seafarers require assessment and rapid medical treatment. We conducted an epidemiological study of the maritime teleconsultations carried out by the French Telemedical Maritime Assistance Service (TMAS), where patients navigating in the Southern Indian Ocean zone were advised to disembark on the medical bases in the French Southern Lands, between 2015 and 2020, to receive medical treatment.

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Article Synopsis
  • Monoclonal antibodies are increasingly important in medicine, but they often have low stability in liquid form, making freeze-drying the preferred method for preserving them.
  • The optimization of the freeze-drying process is crucial for meeting quality and safety standards set by regulatory authorities while also reducing time and energy costs.
  • This review focuses on recent literature regarding the freeze-drying of monoclonal antibodies, highlighting strategies for improving their stability and optimizing the overall process.
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A characteristic of living systems is their ability to self-organize. Using appropriate quantum mechanical and mathematical tools, we show that this ability may also be a characteristic of non-living systems, such as the electron, thus establishing an unsuspected relationship between biology and physics, whereby "biology precedes physics". Planck's constant h is not a pure number but an elementary quantum of action, a "real atom" according to Henri Poincaré.

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