Publications by authors named "J L Ashton"
Background: There is a significant association between low vitamin D levels at diagnosis of indolent B-cell lymphomas and inferior overall survival (OS). To determine whether supplemental vitamin D improves event-free survival (EFS) in these patients, we conducted a comparative double-blind study of vitamin D vs. placebo.
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- - The study assessed the effectiveness of an FDA-cleared AI tool (Koios DS Thyroid) for identifying malignancy in thyroid nodules via ultrasound by analyzing 649 nodules and their pathology results.
- - It compared four groups: AI with and without an adapter, clinical radiology reports, and radiology reports combined with the AI-adapter, focusing on metrics like sensitivity and specificity.
- - Results indicated that the AI with adapter performed equally to radiologists in overall accuracy but had better specificity and decreased sensitivity; the best outcomes were achieved when combining both radiology reports and the AI-adapter.
Editorial: Prediction in Inflammatory Bowel Disease-Do the Answers Lie in Big Clinical Data?
Aliment Pharmacol Ther
December 2024
The circulating methylome in childhood-onset inflammatory bowel disease.
J Crohns Colitis
October 2024
The genetic contribution to inflammatory bowel disease (IBD) encompassing both Crohn's disease (CD) and ulcerative colitis (UC), accounts for around 20% of disease variance, highlighting the need to characterise environmental and epigenetic influences. Recently considerable progress has been made in characterising the adult methylome, in epigenome-wide association studies. We report detailed analysis of the circulating methylome in 86 patients with childhood-onset CD,UC and 30 controls using the Illumina Infinium Human MethylationEPIC platform.
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